Many researchers are beginning to wonder about the links between cancer and Chronic Fatigue Syndrome (CFS). I suppose the emphasis of this is being driven by the news in 2009 about XMRV retrovirus. (Suggestion: put XMRV in the search engine box on this website and read more about what’s happening, plus check out a link that I have posted in the middle column titled, “About.com’s XMRV Discovery series.” Each listing contains good information.)
But recently printed in a medical article titled, “Immunlogical Similarities Between Cancer and Chronic Fatigue Syndrome,” researchers are looking more closely into this matter. Authors Meeus M., Mistiaen W., Lambrecht L., Nijs J. all conclude that:
Cancer and chronic fatigue syndrome (CFS) are both characterised by
fatigue and severe disability. Besides fatigue, certain aspects of
immune dysfunctions appear to be present in both illnesses. In this
regard, a literature review of overlapping immune dysfunctions in CFS
and cancer is provided. Special emphasis is given to the relationship
between immune dysfunctions and fatigue.
I can’t find the web listing for this article anywhere except on other blogs, so I’m listing it here in its entirety. If one of the authors will provide a web address, I will be happy to modify my post. Until then, here is the rest of the report:
Abnormalities in ribonuclease (RNase) L and hyperactivation of nuclear factor kappa beta (NF-kappaB) are present in CFS and in prostate cancer. Malfunctioning of natural killer (NK) cells has long been recognised as an important factor in the development and reoccurrence of cancer, and has been documented repeatedly in CFS patients. The dysregulation of the RNase L pathway, hyperactive NF-kappaB leading to disturbed apoptotic mechanisms and oxidative stress or excessive nitric oxide, and low NK activity may play a role in the two diseases and in the physiopathology of the common symptom fatigue.
However, in cancer the relation between the immune dysfunctions and fatigue has been poorly studied. Immunological abnormalities to such as a dysregulated RNase L pathway, hyperactive NF-kappaB, increased oxidative stress and reduced NK cytotoxicity, among others, are present in both diseases. These anomalies may be part of the physiopathology of some of the common complaints, such as fatigue. Further studies to confirm the hypotheses given here are warranted.
When we finally get all of this data compiled and the facts worked out as to specific links to XMRV retrovirus, cancer in general and Chronic Fatigue Syndrome specifically, we will have a better handle on the situation and be able to approach it with the objective of coming out with specific, time-saving, health-promoting solutions.
Thank you for checking in the with Health Matters Show today.
Your host, Cinda Crawford
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